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Dyslipidaemia Global Newsletter #2 Dyslipi
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CLINICAL PEARLS FROM THE FACULTY FOR THE LINK TO FULL aim ead
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PROF. SANTOS’ THOUGHTS ON ADHERENCE
TO SINGLE-PILL AND TWO-PILL COMBINATION
THERAPY IN CLINICAL PRACTICE.

Prevalence of statin intolerance: A meta-analysis.

Bytyçi I, et al. Eur Heart J. 2022 Feb 16:ehac015. doi: 10.1093/eurheartj/ehac015. Online ahead of print.

Statin intolerance can be over-estimated and over-diagnosed. Even though the long-term safety of statin treatment is well
documented, statin intolerance remains an important clinical challenge, and stopping stating therapy is associated with an
increased risk of CV events. This is the first meta-analysis to examine statin intolerance worldwide and provides estimates for the
overall prevalence of statin intolerance and the prevalence according to different diagnostic criteria, different disease settings, and
identifies possible risk factors and conditions that might increase the risk.

Based on the analysis of >4 million patients in Worldwide prevalence of statin intolerance and risk factors/conditions
176 studies, the prevalence of statin intolerance that affect or do not affect the risk of statin intolerance
was found to be low (9.1%), and even lower
using the international definitions (National Lipid
Association 7.0%; International Lipid Expert
Panel 6.7%; European Atherosclerosis Society
5.9%), suggesting that it may be overestimated in
real world practice.

Female gender, hypothyroidism, high statin dose,
advanced age, antiarrhythmics, and obesity
are the main factors that increase the risk of
statin intolerance. Smoking, duration of statin
therapy, and anticoagulant drugs such as warfarin
were not associated with statin intolerance.
While Hispanic and Caucasian race were not
associated with statin intolerance, Black and
Asian races were.

Perceived statin intolerance remains an important
clinical challenge. Clinicians can use these
results to encourage adherence to statin therapy
in their patients.

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